Benign Transient Hyperphosphatasemia

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bENIgN trANSIENt hyPErPhoSPhAtASEmIA of ChIlDhooD

Objective: To report a case series of benign transient hyperphosphatasemia of infancy (BTHI). Description (Case report): A series of four girls with BTHI is described. The age range was 11-45 months (median: 13 months). At diagnosis, the serum alkaline phosphatase was 1.16.1 times (median: 1.36) above the reference values. Return to normal values occurred between 7-11 months (median: 9 months)....

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Transient hyperphosphatasemia in children.

Transient Hyperphosphatasemia (TH) is a benign condition in which serum alkaline phosphatase (ALP) is transiently elevated in the absence of other systemic diseases. It mainly occurs in infants and children and very rarely seen in adults. The differential diagnosis may include liver, bone, kidney, intestinal, placental and blood diseases as well as other serious conditions as well as bone fract...

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What is the cause of benign transient hyperphosphatasemia? A study of 35 cases.

In a study of 35 children with benign transient hyperphosphatasemia, I found a marked seasonal clustering of cases after the summer months. Furthermore, plasma 25-hydroxyvitamin D concentrations were almost twice those of controls matched for age and time of year. Many children had evidence of weight loss and one had idiopathic hypercalcemia of infancy. Activities both of liver and bone isoenzy...

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Normal Bone Turnover in Transient Hyperphosphatasemia

Transient hyperphosphatasemia of infancy and early childhood (THI) is characterized by a temporary isolated elevation of serum alkaline phosphatase activity (ALP), predominantly its bone or liver isoform, in either sick or healthy children under 5 years of age. Return to normal ALP levels usually occurs within four months. Spontaneous rise of ALP might concern the physician, especially when tre...

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Transient hyperphosphatasemia of infancy--an insufficiently recognized syndrome.

Spectacular transient increases in serum alkaline phosphatase were observed in five infants in the absence of demonstrable pathology.

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ژورنال

عنوان ژورنال: Research in Pediatrics & Neonatology

سال: 2019

ISSN: 2576-9200

DOI: 10.31031/rpn.2019.04.000578